Circulating malignant lymphocytes from Sezary syndrome express high level of glycoproteins carrying beta (1-6)N-acetylglucosamine-branched N-linked oligosaccharides.

Abstract : The circulating forms of malignant cells from patients with Sezary syndrome exhibit on their glycoproteins a high level of beta (1-6)GlcNAc-branched N-linked oligosaccharides, a particular species of glycans related to the metastatic potential of several tumors and T lymphocytes activation. An increased activity of the N-acetylglucosaminyltransferase V and of the beta (1-4)galactosyltransferase, two enzymes implicated in beta (1-6)GlcNAc-branching is also found. Nevertheless, contrary to activated normal T lymphocytes, Sezary lymphocytes in agreement with their non-proliferating state, do not exhibit increased thymidine uptake. This result suggests that expression of the beta (1-6)GlcNAc-branched N-linked carbohydrates could be related to some of the malignant properties of Sezary lymphocytes.
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Soumis le : lundi 28 janvier 2019 - 16:25:26
Dernière modification le : jeudi 11 avril 2019 - 16:02:59

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  • HAL Id : hal-01996974, version 1
  • PUBMED : 8558919

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C. Derappe, G. Haentjens, S. Lemaire, J Feugeas, V. Pasqualetto, et al.. Circulating malignant lymphocytes from Sezary syndrome express high level of glycoproteins carrying beta (1-6)N-acetylglucosamine-branched N-linked oligosaccharides.. Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 1996, 10 (1), pp.138-41. ⟨hal-01996974⟩

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